APAF1 O14727

凋亡蛋白酶激活因子1 (APAF-1)

蛋白质信息 (UniProt)

凋亡蛋白酶激活因子1 (APAF-1)

O14727

功能描述

寡聚Apaf-1介导pro-caspase-9 (Apaf-3)的细胞色素c依赖性自催化激活，导致caspase-3的激活和细胞凋亡。这种激活需要ATP。Isoform 6在诱导细胞凋亡方面效果较差。 {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}。

组织特异性

Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Apoptosis ATP-binding Calcium Cytoplasm Direct protein sequencing Nucleotide-binding Proteomics identification Reference proteome

外部链接

UniProt: O14727

NCBI Gene

GeneCards