AP-3复合体亚基beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (网格蛋白装配蛋白复合体3 beta-2大链) (神经元特异性囊泡外被蛋白beta-NAP)
AP-3复合体亚基beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (网格蛋白装配蛋白复合体3 beta-2大链) (神经元特异性囊泡外被蛋白beta-NAP)
Q13367功能描述
非网格蛋白和网格蛋白相关 adaptor protein complex 3 (AP-3) 的亚基，在 late-Golgi/trans-Golgi network (TGN) 和/或 endosomes 的 protein sorting 中发挥作用。AP 复合物介导 grid protein 到膜上的募集以及对 transmembrane cargo molecules 胞质尾部内 sorting signals 的识别。AP-3 似乎参与 sorting 靶向 lysosomes 和 lysosome-related organelles 的 transmembrane proteins 亚群。与 BLOC-1 复合物协同作用，AP-3 是将 cargos 靶向至细胞体处组装的 vesicles 以便递送至 neurites 和 nerve terminals 所必需的。
组织特异性
Isoform 1 expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression) (PubMed:1851215). Isoform 2 is expressed at high levels in brain and testis (PubMed:17453999).
亚细胞定位
Cytoplasmic vesicle, clathrin-coated vesicle membrane
关键词