氨肽酶N (AP-N) (hAPN) (EC 3.4.11.2) (丙氨酸氨肽酶) (氨肽酶M) (AP-M) (微粒体氨肽酶) (髓系血浆膜糖蛋白CD13) (gp150) (CD抗原CD13)
氨肽酶N (AP-N) (hAPN) (EC 3.4.11.2) (丙氨酸氨肽酶) (氨肽酶M) (AP-M) (微粒体氨肽酶) (髓系血浆膜糖蛋白CD13) (gp150) (CD抗原CD13)
P15144功能描述
广谱特异性氨基肽酶，在胃和胰腺蛋白酶水解蛋白质产生的肽的最终消化中发挥作用。也参与多种肽的加工，包括肽激素，如血管紧张素III和IV、神经肽和趋化因子。可能还参与抗原呈递细胞主要组织相容性复合体II类分子结合肽的裂解。可能在血管生成中发挥作用并促进胆固醇结晶。可能通过作为氨基酸转运蛋白SLC6A19的结合伴侣并调节其活性，在氨基酸转运中发挥作用（通过相似性）。{ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; FUNCTION: (Microbial infection) 作为人冠状病毒229E/HCoV-229E的受体。在人冠状病毒229E (HCoV-229E) 感染的情况下，作为HCoV-229E刺突糖蛋白的受体。{ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; FUNCTION: (Microbial infection) 也介导人巨细胞病毒 (HCMV) 感染。{ECO:0000269|PubMed:8105105}.
组织特异性
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
亚细胞定位
Cell membrane
关键词