ANLN Q9NQW6

锚蛋白

功能描述

胞质分裂所必需 (PubMed:16040610)。对于分裂沟的结构完整性及分裂沟内陷的完成至关重要。在有丝分裂的中期和后期，在bleb组装中发挥作用 (PubMed:23870127)。可能在足细胞迁移中发挥重要作用 (PubMed:24676636)。 {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}。

组织特异性

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

亚细胞定位

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex