ALKAL2 Q6UX46

ALK和LTK配体2 (Augmentor alpha) (AUG-alpha)

蛋白质信息 (UniProt)

ALK和LTK配体2 (Augmentor alpha) (AUG-alpha)

Q6UX46

功能描述

作为受体酪氨酸激酶LTK和ALK的生理性配体发挥作用的细胞因子，导致其激活 (PubMed:26418745, PubMed:26630010, PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673)。细胞因子结合足以激活LTK (PubMed:34646012)。相比之下，ALKAL2驱动的ALK激活与肝素结合ALK有关 (PubMed:34646012)。刺激ALK信号传导参与神经发育和能量消耗的调节 (PubMed:34646012, PubMed:34819673)。 {ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}。

组织特异性

Widely expressed with highest levels in adrenal gland and modest levels in pancreas, testis and uterus.

亚细胞定位

Secreted

关键词

3D-structure Alternative splicing Cell membrane Cytokine Direct protein sequencing Disulfide bond Membrane Proteomics identification Reference proteome Secreted

外部链接

UniProt: Q6UX46

NCBI Gene

GeneCards