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ALDH9A1 P49189

4-三甲氨基丁醛脱氢酶 (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (醛脱氢酶E3同工酶) (醛脱氢酶家族9成员A1) (EC 1.2.1.3) (甲醛脱氢酶) (EC 1.2.1.46) (γ-氨基丁醛脱氢酶) (EC 1.2.1.19) (R-氨基丁醛脱氢酶) [切割为:4-三甲氨基丁醛脱氢酶,N端加工]

蛋白质信息 (UniProt)

4-三甲氨基丁醛脱氢酶 (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (醛脱氢酶E3同工酶) (醛脱氢酶家族9成员A1) (EC 1.2.1.3) (甲醛脱氢酶) (EC 1.2.1.46) (γ-氨基丁醛脱氢酶) (EC 1.2.1.19) (R-氨基丁醛脱氢酶) [切割为:4-三甲氨基丁醛脱氢酶,N端加工]

P49189

功能描述

高效将gamma-三甲氨基丁醛转化为gamma-丁酰甜菜碱(体外)。可以在依赖NAD的反应中催化多种醛不可逆地氧化为相应的酸,但效率较低。催化由生物胺和多胺产生的醛的氧化。 {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:1799975, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}。

组织特异性

Detected in brain (at protein level) (PubMed:8645224). High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain (PubMed:8786138). Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole.

亚细胞定位

Cytoplasm, cytosol

关键词

3D-structure Acetylation Alternative initiation Alternative splicing Cytoplasm Direct protein sequencing NAD Oxidoreductase Proteomics identification Reference proteome