ALCAM Q13740

CD166抗原 (活化白细胞黏附分子) (CD抗原CD166)

功能描述

细胞粘附分子，通过与CD6相互作用介导异型细胞-细胞接触，以及同型细胞-细胞接触 (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007)。通过与CD6的相互作用促进T细胞活化和增殖 (PubMed:15048703, PubMed:16352806, PubMed:24945728)。通过与CD6的相互作用参与免疫突触的形成和成熟 (PubMed:15294938, PubMed:16352806)。介导与表达ALCAM的细胞进行同型相互作用 (PubMed:15496415, PubMed:16352806)。作为LILRB4受体的配体，增强LILRB4介导的T细胞增殖抑制 (PubMed:29263213)。正常造血干细胞在骨髓中植入所必需 (PubMed:24740813)。通过同型相互作用介导树突状细胞附着于内皮细胞 (PubMed:23169771)。抑制内皮细胞迁移并通过同型相互作用促进内皮管形成 (PubMed:15496415, PubMed:23169771)。淋巴管网络正常组织所必需。正常造血干细胞在骨髓中植入所必需。在造血中发挥作用；骨髓中正常数量的造血干细胞所必需。促进体外成骨细胞增殖和分化 (By similarity)。促进神经突延伸、轴突生长和轴突导向；轴突优先在含有ALCAM的表面上生长。介导视网膜神经节细胞轴突的生长和路径寻找 (By similarity)。 {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:29263213, ECO:0000269|PubMed:7760007}.; FUNCTION: [Isoform 3]: 通过竞争相同的相互作用伴侣，抑制膜结合型异构体的活性。通过同型相互作用抑制细胞附着。促进内皮细胞迁移。抑制内皮细胞管形成。 {ECO:0000269|PubMed:15496415}.

组织特异性

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).

亚细胞定位

Cell membrane