醛-酮还原酶家族1成员C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-β-羟基类固醇脱氢酶5型) (17-β-HSD 5) (3-α-HSD II型, 脑) (3-α-羟基类固醇脱氢酶2型) (3-α-HSD 2型) (EC 1.1.1.357) (氯丹还原酶同源物HAKRb) (二氢二醇脱氢酶3) (DD-3) (DD3) (二氢二醇脱氢酶I型) (HA1753) (前列腺素F合酶) (PGFS) (EC 1.1.1.188) (睾酮17-β-脱氢酶5) (EC 1.1.1.239, EC 1.1.1.64)
醛-酮还原酶家族1成员C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-β-羟基类固醇脱氢酶5型) (17-β-HSD 5) (3-α-HSD II型, 脑) (3-α-羟基类固醇脱氢酶2型) (3-α-HSD 2型) (EC 1.1.1.357) (氯丹还原酶同源物HAKRb) (二氢二醇脱氢酶3) (DD-3) (DD3) (二氢二醇脱氢酶I型) (HA1753) (前列腺素F合酶) (PGFS) (EC 1.1.1.188) (睾酮17-β-脱氢酶5) (EC 1.1.1.239, EC 1.1.1.64)
P42330功能描述
胞质醛酮还原酶，催化NADPH依赖的酮类固醇还原为羟基类固醇。具有广泛的底物特异性，具有独特的位置和立体化学特性，主要生成17beta-羟基类固醇，但也生成3alpha-和20alpha-羟基类固醇 (PubMed:10998348, PubMed:11165022, PubMed:20036328, PubMed:9415401, PubMed:9927279, PubMed:10998348, PubMed:9927279)。通过经典和'后门'/替代途径产生强效雄激素。在经典雄激素代谢途径（经睾酮生物合成5alpha-双氢睾酮 (5alpha-DHT)）中，催化delta4-雄烯二酮还原形成睾酮 (PubMed:10998348, PubMed:11165022, PubMed:20036328, PubMed:9415401, PubMed:9927279)。在'后门'雄激素代谢途径（经孕烷生物合成5alpha-双氢睾酮 (5alpha-DHT)）中，将雄酮还原为5alpha-雄烷-3alpha,17beta-二醇，先于5alpha-DHT的分泌 (PubMed:10557352, PubMed:10998348, PubMed:9415401)。将5alpha-DHT还原为活性较低的雄激素5alpha-雄烷-3alpha,17beta-二醇，可能调节雄激素受体的配体可用性 (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401)。可能参与肾上腺来源的雄激素前体的代谢。分别将11-酮-4-雄烯-3,17-二酮 (11KA4) 和11-酮-5alpha-雄烷-3,17-二酮 (11K-Adione) 还原为强效雄激素11-酮睾酮 (11KT) 和11-酮双氢睾酮 (11KDHT) (PubMed:31926269)。在雌激素代谢中，催化雌酮转化为强效雌激素17beta-雌二醇 (PubMed:10998348, PubMed:11165022, PubMed:20036328)。作为前列腺素 (PG) F2alpha 合酶发挥作用。显示11-酮还原酶和9,11-内过氧化物还原酶活性，并将PGD2还原为11beta-PGF2alpha，将PGH2还原为PGF2alpha (PubMed:10622721, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328, PubMed:7650035, PubMed:9415401, PubMed:9927279)。还对9-顺式视黄醛显示视黄醛还原酶活性 (PubMed:21851338)。在体外，可以利用NADPH/NADP(+)或NADH/NAD(+)作为辅因子有效催化酮类固醇和羟基类固醇之间的双向转化。然而在体内，还原酶活性占主导地位，因为主要还原辅因子NADPH抑制了NAD(+)-依赖的氧化酶活性 (PubMed:11165022, PubMed:14672942)。此外，它能够在体外还原各种羰基化合物，如甲萘醌、菲醌和硝基苯甲醛 (By similarity)。 {ECO:0000250|UniProtKB:P05980, ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:31926269, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
组织特异性
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. High expression in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
亚细胞定位
Cytoplasm
关键词