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AKAP7 O43687

A-激酶锚定蛋白7 α和β异构体 (AKAP-7 isoforms alpha and beta) (A-激酶锚定蛋白 18 kDa) (AKAP 18) (蛋白激酶A锚定蛋白7 α/β异构体) (PRKA7 isoforms alpha/beta)

蛋白质信息 (UniProt)

A-激酶锚定蛋白7 α和β异构体 (AKAP-7 isoforms alpha and beta) (A-激酶锚定蛋白 18 kDa) (AKAP 18) (蛋白激酶A锚定蛋白7 α/β异构体) (PRKA7 isoforms alpha/beta)

O43687

功能描述

将cAMP依赖性蛋白激酶(PKA)靶向至质膜,并允许其与L型钙通道进行功能偶联。膜结合形式降低上皮钠通道(ENaC)活性,而游离的细胞质形式可能负向调节细胞内钠对ENaC通道的反馈抑制。 {ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820, ECO:0000269|PubMed:9545239}。

组织特异性

Expressed in brain, heart, lung, pancreas and skeletal muscle.

亚细胞定位

[Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.; SUBCELLULAR LOCATION: [Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.

关键词

Alternative splicing Cell membrane Lipoprotein Membrane Myristate Palmitate Proteomics identification Reference proteome