AK3 Q9UIJ7

GTP:AMP磷酸转移酶AK3，线粒体 (EC 2.7.4.10) (腺苷酸激酶3) (腺苷酸激酶3α样1) (腺苷酸激酶同工酶3)

蛋白质信息 (UniProt)

GTP:AMP磷酸转移酶AK3，线粒体 (EC 2.7.4.10) (腺苷酸激酶3) (腺苷酸激酶3α样1) (腺苷酸激酶同工酶3)

Q9UIJ7

功能描述

具有特异性GTP:AMP磷酸转移酶活性的线粒体腺苷酸激酶 (PubMed:11485571, PubMed:32822537)。也可以使用ITP作为磷酸供体 (PubMed:11485571)。其生理功能是将GTP循环转化为GDP，这对于线粒体基质中的TCA循环是必需的 (Probable)。 {ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:32822537, ECO:0000305|PubMed:11485571, ECO:0000305|PubMed:35457131}。

组织特异性

Highly expressed in heart, skeletal muscle and liver, moderately expressed in pancreas and kidney, and weakly expressed in placenta, brain and lung.

亚细胞定位

Mitochondrion matrix

关键词

3D-structure Acetylation Alternative splicing GTP-binding Kinase Ligase Mitochondrion Nucleotide-binding Phosphoprotein Proteomics identification

外部链接

UniProt: Q9UIJ7

NCBI Gene

GeneCards