AK2 P54819

腺苷酸激酶2，线粒体 (AK 2) (EC 2.7.4.3) (ATP-AMP转磷酸酶2) (ATP:AMP磷酸转移酶) (腺苷一磷酸激酶) [裂解为：腺苷酸激酶2，线粒体，N端加工]

功能描述

催化ATP和AMP之间末端磷酸基团的可逆转移。在细胞能量稳态和腺嘌呤核苷酸代谢中起重要作用。腺苷酸激酶活性对于磷酸利用和AMP从头合成途径的调节至关重要。在造血过程中起关键作用。 {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}。

组织特异性

Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).

亚细胞定位

Mitochondrion intermembrane space