AK1 P00568

腺苷酸激酶同工酶1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP转磷酸酶1) (ATP:AMP磷酸转移酶) (腺苷一磷酸激酶) (肌激酶)

蛋白质信息 (UniProt)

腺苷酸激酶同工酶1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP转磷酸酶1) (ATP:AMP磷酸转移酶) (腺苷一磷酸激酶) (肌激酶)

P00568

功能描述

催化ATP和AMP之间末端磷酸基团的可逆转移。也表现出广泛的核苷二磷酸激酶活性。在细胞能量稳态和腺嘌呤核苷酸代谢中起重要作用 (By similarity) (PubMed:21080915, PubMed:23416111, PubMed:2542324)。也以极低的速率催化由硫胺素二磷酸 (ThDP) 和ADP合成硫胺素三磷酸 (ThTP) (By similarity)。 {ECO:0000250|UniProtKB:P05081, ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:2542324}.

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation ATP-binding Cytoplasm Direct protein sequencing Disease variant Hereditary hemolytic anemia Kinase Nucleotide-binding Phosphoprotein

外部链接

UniProt: P00568

NCBI Gene

GeneCards