AGR3 Q8TD06

前梯度蛋白3 (AG-3) (AG3) (hAG-3) (前梯度3同源物) (乳腺癌膜蛋白11) (蛋白质二硫键异构酶家族A成员18)

功能描述

气道中钙介导的纤毛摆动频率和粘液纤毛清除调节所必需的。可能参与气管上皮细胞内钙的调节。 {ECO:0000250|UniProtKB:Q8R3W7}。

组织特异性

Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690).

亚细胞定位

Endoplasmic reticulum