凋亡增强核酸酶 (EC 3.1.-.-) (干扰素刺激的20 kDa核酸外切酶样1)
凋亡增强核酸酶 (EC 3.1.-.-) (干扰素刺激的20 kDa核酸外切酶样1)
Q8WTP8功能描述
具有针对单链和双链DNA及RNA活性的核酸外切酶。介导p53诱导的细胞凋亡。在DNA损伤后被p53诱导，消化双链DNA形成单链DNA并放大DNA损伤信号，从而增强细胞凋亡。 {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}。
亚细胞定位
Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
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