ADRM1 Q16186

蛋白酶体泛素受体 ADRM1 (110 kDa 细胞膜糖蛋白) (Gp110) (粘附调节分子 1) (ARM-1) (蛋白酶体调节颗粒非ATP酶 13) (hRpn13) (Rpn13 同源物)

功能描述

26S proteasome的组分，该multiprotein complex参与ubiquitinated proteins的ATP依赖性降解 (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872)。该complex通过清除可能损害细胞功能的错误折叠或受损蛋白，以及清除不再需要其功能的蛋白，在维持protein稳态中发挥关键作用 (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872)。因此，proteasome参与众多细胞过程，包括细胞周期进程、细胞凋亡或DNA损伤修复 (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872)。在该complex内，作为proteasomal ubiquitin受体发挥作用 (PubMed:18497817)。在protein降解过程中结合并激活19S相关的deubiquitinases UCHL5和PSMD14 (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541)。UCHL5可逆地与19S regulatory particle结合，而PSMD14是proteasome lid subcomplex的内在亚基 (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541)。 {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}。

亚细胞定位

Cytoplasm