ADRA1A P35348

Alpha-1A肾上腺素能受体 (Alpha-1A肾上腺素受体) (Alpha-1A肾上腺素受体) (Alpha-1C肾上腺素能受体) (Alpha-肾上腺素能受体1c)

功能描述

Alpha-1肾上腺素受体是儿茶酚胺的G蛋白偶联受体，通过G蛋白G(q)家族（包括G(q)和G(11)）进行信号传导。激活后，它们刺激磷脂酰肌醇-钙第二信使通路，导致钙从细胞内储存中释放并激活蛋白激酶C (PubMed:37563160)。ADRA1A结合儿茶酚胺配体去甲肾上腺素和肾上腺素 (PubMed:18802028, PubMed:37563160, PubMed:7815325, PubMed:8024574, PubMed:8183249, PubMed:8832064)。也可以偶联G(14)蛋白 (By similarity)。细胞核ADRA1A与ADRA1B形成异源寡聚体，以调节心肌细胞中去氧肾上腺素(PE)刺激的ERK信号传导 (PubMed:18802028, PubMed:22120526)。在质膜处，ADRA1A与CAVIN4/MURC相互作用以调节心肌细胞中的ERK激活，有助于调节心肌肥大 (PubMed:24567387)。此外，在阻力动脉中作为血管加压剂发挥作用，并在维持正常动脉血压中起作用 (By similarity)。 {ECO:0000250|UniProtKB:P18130, ECO:0000250|UniProtKB:P97718, ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526, ECO:0000269|PubMed:24567387, ECO:0000269|PubMed:37563160, ECO:0000269|PubMed:7815325, ECO:0000269|PubMed:8024574, ECO:0000269|PubMed:8183249, ECO:0000269|PubMed:8832064}。

组织特异性

Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

亚细胞定位

Nucleus membrane