ADP-核糖水解酶 ARH3 (ADP-核糖糖水解酶 ARH3) (ADP-核糖水解酶 3) (O-乙酰-ADP-核糖脱乙酰酶 ARH3) (EC 3.5.1.-) (聚(ADP-核糖)糖水解酶 ARH3) (EC 3.2.1.143) ([蛋白质ADP-核糖精氨酸]水解酶样蛋白 2) ([蛋白质ADP-核糖丝氨酸]水解酶) (EC 3.2.2.-)
ADP-核糖水解酶 ARH3 (ADP-核糖糖水解酶 ARH3) (ADP-核糖水解酶 3) (O-乙酰-ADP-核糖脱乙酰酶 ARH3) (EC 3.5.1.-) (聚(ADP-核糖)糖水解酶 ARH3) (EC 3.2.1.143) ([蛋白质ADP-核糖精氨酸]水解酶样蛋白 2) ([蛋白质ADP-核糖丝氨酸]水解酶) (EC 3.2.2.-)
Q9NX46功能描述
ADP-核糖水解酶，优先水解连接在ADP-核糖异头C1''位置上的关键alpha-O-键，并作用于不同的底物，如在丝氨酸和苏氨酸上发生ADP-核糖基化的蛋白质、游离聚腺苷二磷酸核糖和O-乙酰基-ADP-D-核糖 (PubMed:21498885, PubMed:29907568, PubMed:30045870, PubMed:30401461, PubMed:30830864, PubMed:33186521, PubMed:33769608, PubMed:33894202, PubMed:34019811, PubMed:34321462, PubMed:34479984, PubMed:34625544)。特异性地作为丝氨酸单ADP-核糖水解酶，介导去除蛋白质上连接在丝氨酸残基上的单ADP-核糖，从而在DNA损伤反应中发挥关键作用 (PubMed:28650317, PubMed:29234005, PubMed:30045870, PubMed:33186521, PubMed:34019811, PubMed:34625544)。蛋白质的丝氨酸ADP-核糖基化构成了DNA损伤反应中蛋白质ADP-核糖基化的主要形式 (PubMed:29480802, PubMed:33186521, PubMed:34625544)。不水解ADP-核糖基-精氨酸、-半胱氨酸、-白喉酰胺或-天冬酰胺键 (PubMed:16278211, PubMed:33769608)。也能降解蛋白质游离聚腺苷二磷酸核糖，该物质在DNA损伤反应中合成：游离聚腺苷二磷酸核糖充当强效的细胞死亡信号，其被ADPRHL2降解可保护细胞免受聚腺苷二磷酸核糖依赖性细胞死亡，该过程称为parthanatos (PubMed:16278211)。也能水解线粒体中的游离聚腺苷二磷酸核糖 (PubMed:22433848)。特异性消化O-乙酰基-ADP-D-核糖，这是sirtuins催化的去乙酰化反应的产物 (PubMed:17075046, PubMed:21498885)。特异性降解1''-O-乙酰基-ADP-D-核糖异构体，而非2''-O-乙酰基-ADP-D-核糖或3''-O-乙酰基-ADP-D-核糖异构体 (PubMed:21498885)。 {ECO:0000269|PubMed:16278211, ECO:0000269|PubMed:17075046, ECO:0000269|PubMed:21498885, ECO:0000269|PubMed:22433848, ECO:0000269|PubMed:28650317, ECO:0000269|PubMed:29234005, ECO:0000269|PubMed:29480802, ECO:0000269|PubMed:29907568, ECO:0000269|PubMed:30045870, ECO:0000269|PubMed:30401461, ECO:0000269|PubMed:30830864, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33769608, ECO:0000269|PubMed:33894202, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462, ECO:0000269|PubMed:34479984, ECO:0000269|PubMed:34625544}。
组织特异性
Ubiquitous (PubMed:16278211). Expressed in skin fibroblasts (PubMed:30830864).
亚细胞定位
Nucleus
关键词