返回首页

ADIPOR1 Q96A54

脂联素受体蛋白1 (孕激素和adipoQ受体家族成员1) (孕激素和adipoQ受体家族成员I)

蛋白质信息 (UniProt)

脂联素受体蛋白1 (孕激素和adipoQ受体家族成员1) (孕激素和adipoQ受体家族成员I)

Q96A54

功能描述

ADIPOQ的受体,ADIPOQ是脂肪细胞分泌的一种必需激素,调节葡萄糖和脂质代谢 (PubMed:12802337, PubMed:25855295)。正常的葡萄糖和脂肪稳态以及维持正常体重所必需的。ADIPOQ结合激活信号级联反应,导致AMPK活性增加,最终导致脂肪酸氧化增加、葡萄糖摄取增加和糖异生减少。对球状脂联素具有高亲和力,对全长脂联素具有低亲和力 (By similarity)。 {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}。

组织特异性

Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).

亚细胞定位

Cell membrane

关键词

3D-structure Cell membrane Fatty acid metabolism Lipid metabolism Membrane Metal-binding Proteomics identification Receptor Reference proteome Transmembrane