粘附G蛋白偶联受体E2 (EGF样模块受体2) (含EGF样模块粘蛋白样激素受体样2) (CD抗原CD312)
粘附G蛋白偶联受体E2 (EGF样模块受体2) (含EGF样模块粘蛋白样激素受体样2) (CD抗原CD312)
Q9UHX3功能描述
结合糖胺聚糖链的硫酸软骨素部分并促进细胞附着的细胞表面受体。促进粒细胞趋化、脱颗粒和粘附。在巨噬细胞中，促进炎症细胞因子的释放，包括IL8和TNF。可能通过G蛋白发出信号。是肥大细胞脱颗粒的调节因子 (PubMed:26841242)。 {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:17928360, ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:26841242}。
组织特异性
Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242).
亚细胞定位
Cell membrane
关键词