粘附G蛋白偶联受体B1 (脑特异性血管生成抑制剂1) [切割为: 血管抑素-40 (Vstat40); 血管抑素-120 (Vstat120)]
粘附G蛋白偶联受体B1 (脑特异性血管生成抑制剂1) [切割为: 血管抑素-40 (Vstat40); 血管抑素-120 (Vstat120)]
O14514功能描述
磷脂酰丝氨酸受体，增强凋亡细胞的吞噬 (PubMed:24509909)。也介导革兰氏阴性菌的结合和吞噬 (PubMed:26838550)。刺激巨噬细胞响应革兰氏阴性菌产生活性氧，从而增强巨噬细胞的杀菌活性 (PubMed:26838550)。在胃黏膜中，识别和吞噬凋亡的胃上皮细胞所必需 (PubMed:24509909)。促进成肌细胞融合 (By similarity)。以G蛋白依赖的方式激活Rho通路 (PubMed:23782696)。抑制MDM2介导的DLG4/PSD95泛素化和降解，促进DLG4稳定性并调节突触可塑性 (By similarity)。通过确保PARD3和TIAM1的正确定位，为树突棘的形成所必需 (By similarity)。脑内血管生成的强效抑制剂，可能作为p53/TP53信号抑制胶质母细胞瘤的介导者发挥重要作用 (PubMed:11875720)。 {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: 以CD36依赖的方式抑制血管生成。 {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: 抑制血管生成。 {ECO:0000269|PubMed:22330140}.
组织特异性
Expressed in brain (at protein level) (PubMed:12074842, PubMed:12507886). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level) (PubMed:24509909). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue (PubMed:11875720). Reduced or no expression is observed in some glioblastomas (PubMed:12507886).
亚细胞定位
Cell membrane
关键词