ADCY5 O95622

5型腺苷酸环化酶 (EC 4.6.1.1) (ATP焦磷酸裂解酶5) (腺苷酸环化酶V型) (腺苷酰环化酶5) (AC5)

蛋白质信息 (UniProt)

5型腺苷酸环化酶 (EC 4.6.1.1) (ATP焦磷酸裂解酶5) (腺苷酸环化酶V型) (腺苷酰环化酶5) (AC5)

O95622

功能描述

催化G-protein信号响应中信号分子cAMP的形成 (PubMed:15385642, PubMed:24700542, PubMed:26206488)。介导ADRB1下游的信号传导 (PubMed:24700542)。调节血糖水平升高引起的游离胞质Ca(2+)增加，并参与Ca(2+)依赖性胰岛素分泌的调节 (PubMed:24740569)。 {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}。

组织特异性

Detected in pancreas islets (at protein level). Expressed in the brain, with high expression in the corpus striatum (PubMed:26085604).

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing ATP-binding cAMP biosynthesis Cell membrane Cell projection Cilium Disease variant Glycoprotein Intellectual disability

外部链接

UniProt: O95622

NCBI Gene

GeneCards