含双PH结构域Arf-GAP蛋白1 (Centaurin-alpha-1) (Cnt-a1) (推定MAPK激活蛋白PM25)
含双PH结构域Arf-GAP蛋白1 (Centaurin-alpha-1) (Cnt-a1) (推定MAPK激活蛋白PM25)
O75689功能描述
ADP核糖基化因子家族的GTP酶激活蛋白 (Probable)。结合磷脂酰肌醇3,4,5-三磷酸 (PtdInsP3) 和肌醇1,3,4,5-四磷酸 (InsP4)。调节CD63和CD9整合入多泡体 (PubMed:38682696)。 {ECO:0000269|PubMed:10448098, ECO:0000269|PubMed:38682696, ECO:0000303|PubMed:10333475, ECO:0000305}。
组织特异性
Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.
亚细胞定位
Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
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