ADAM12 O43184

含解整合素样金属蛋白酶结构域蛋白12 (ADAM 12) (EC 3.4.24.-) (Meltrin-α)

功能描述

参与骨骼肌再生，特别是在细胞融合开始时。也参与单核前体细胞形成的巨噬细胞来源的多核巨细胞（MGC）和破骨细胞（通过相似性）。{ECO:0000250}。

组织特异性

Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.

亚细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted