酰基辅酶A硫酯酶8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (胆酰辅酶A硫酯酶) (EC 3.1.2.27) (HIV-Nef相关酰基辅酶A硫酯酶) (过氧化物酶体酰基辅酶A硫酯酶2) (PTE-2) (过氧化物酶体酰基辅酶A硫酯水解酶1) (PTE-1) (过氧化物酶体长链酰基辅酶A硫酯酶1) (硫酯酶II) (hACTE-III) (hACTEIII) (hTE)
酰基辅酶A硫酯酶8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (胆酰辅酶A硫酯酶) (EC 3.1.2.27) (HIV-Nef相关酰基辅酶A硫酯酶) (过氧化物酶体酰基辅酶A硫酯酶2) (PTE-2) (过氧化物酶体酰基辅酶A硫酯水解酶1) (PTE-1) (过氧化物酶体长链酰基辅酶A硫酯酶1) (硫酯酶II) (hACTE-III) (hACTEIII) (hTE)
O14734功能描述
催化acyl-CoAs水解为游离脂肪酸和辅酶A (CoASH)，调节它们各自的细胞内水平 (PubMed:15194431, PubMed:9153233, PubMed:9299485)。对Acyl-CoAs的羧酸部分未显示出强烈的底物特异性 (By similarity)。水解中等链长 (C2至C20) 直链、饱和及不饱和acyl-CoAs，但对具有更长脂肪链的底物无活性 (PubMed:9153233, PubMed:9299485)。此外，它催化胆汁酸CoA酯的水解，如choloyl-CoA和chenodeoxycholoyl-CoA，并与胆汁酸CoA:氨基酸N-酰基转移酶 (BAAT) 竞争 (By similarity)。也能水解二羧酸的CoA酯 (By similarity)。它参与过氧化物酶体增殖的代谢调节 (PubMed:15194431)。 {ECO:0000250|UniProtKB:P58137, ECO:0000269|PubMed:15194431, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485}.; FUNCTION: (微生物感染) 可能介导Nef诱导的CD4细胞表面表达下调 (PubMed:9153233)。 {ECO:0000269|PubMed:9153233}.
组织特异性
Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485).
亚细胞定位
Peroxisome matrix
关键词