ACOT2 P49753

酰基辅酶A硫酯酶2，线粒体 (酰基CoA硫酯酶2) (EC 3.1.2.2) (酰基辅酶A硫酯水解酶2a) (CTE-Ia) (长链酰基CoA硫酯酶2) (ZAP128)

蛋白质信息 (UniProt)

酰基辅酶A硫酯酶2，线粒体 (酰基CoA硫酯酶2) (EC 3.1.2.2) (酰基辅酶A硫酯水解酶2a) (CTE-Ia) (长链酰基CoA硫酯酶2) (ZAP128)

P49753

功能描述

催化酰基辅酶A水解为游离脂肪酸和辅酶A (CoASH)，调节它们各自的细胞内水平 (PubMed:10944470, PubMed:16940157)。对长链酰基辅酶A (C14-C20) 显示出较高的活性 (PubMed:10944470, PubMed:16940157)。该enzyme参与增强线粒体中的肝脏脂肪酸氧化 (By similarity)。 {ECO:0000250|UniProtKB:Q9QYR9, ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}.

组织特异性

Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.

亚细胞定位

Mitochondrion

关键词

3D-structure Acetylation Alternative splicing Fatty acid metabolism Hydrolase Lipid metabolism Mitochondrion Proteomics identification Reference proteome Serine esterase

外部链接

UniProt: P49753

NCBI Gene

GeneCards