ACKR3 P25106

非典型趋化因子受体3 (C-X-C趋化因子受体7型) (CXC-R7) (CXCR-7) (趋化因子孤儿受体1) (G蛋白偶联受体159) (G蛋白偶联受体RDC1同源物) (RDC-1)

功能描述

非典型趋化因子受体，通过高亲和力趋化因子结合控制趋化因子的水平和定位，该结合与经典的配体驱动信号转导级联反应解偶联，从而导致趋化因子隔离、降解或跨细胞转运。也被称为拦截受体（内化受体）或趋化因子清除受体或趋化因子诱饵受体。作为趋化因子CXCL11和CXCL12/SDF1的受体 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987)。趋化因子结合不激活G蛋白介导的信号转导，而是诱导β-arrestin募集，导致配体内化和MAPK信号通路激活 (PubMed:16940167, PubMed:18653785, PubMed:20018651)。迁移中间神经元中CXCR4蛋白水平的调节所必需的，从而适应其趋化因子反应性 (PubMed:16940167, PubMed:18653785)。在胶质瘤细胞中，通过MEK/ERK通路转导信号，介导细胞凋亡抗性。促进细胞生长和存活 (PubMed:16940167, PubMed:20388803)。不参与正常造血祖细胞的细胞迁移、粘附或增殖，但在恶性造血细胞中被CXCL11激活，导致ERK1/2 (MAPK3/MAPK1) 磷酸化并增强细胞粘附和迁移 (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389)。在CXCL12介导的CXCR4激活细胞表面整合素中起调节作用 (PubMed:18653785)。心脏瓣膜发育所必需的 (PubMed:17804806)。通过调节CXCL12水平调节动眼神经系统的轴突导向 (PubMed:31211835)。作为SHLP2的受体，介导其对下丘脑弓状核中阿黑皮素原神经元激活的影响，从而导致食物摄入抑制和能量消耗增加 (PubMed:37468558)。 {ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:16940167, ECO:0000269|PubMed:17804806, ECO:0000269|PubMed:18653785, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:19380869, ECO:0000269|PubMed:19641136, ECO:0000269|PubMed:20018651, ECO:0000269|PubMed:20161793, ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389, ECO:0000269|PubMed:22300987, ECO:0000269|PubMed:31211835, ECO:0000269|PubMed:37468558}.; FUNCTION: (Microbial infection) 作为CXCR4的共受体，用于有限数量的HIV分离株。 {ECO:0000305|PubMed:23153575}.

组织特异性

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level).

亚细胞定位

Cell membrane