1-酰基甘油-3-磷酸O-酰基转移酶ABHD5 (EC 2.3.1.51) (含水解酶结构域蛋白5) (脂滴结合蛋白CGI-58)
1-酰基甘油-3-磷酸O-酰基转移酶ABHD5 (EC 2.3.1.51) (含水解酶结构域蛋白5) (脂滴结合蛋白CGI-58)
Q8WTS1功能描述
辅酶A依赖性溶血磷脂酸酰基转移酶，催化酰基转移至溶血磷脂酸 (PubMed:18606822)。优先以1-油酰溶血磷脂酸为脂质受体，其次为1-棕榈酰溶血磷脂酸、1-硬脂酰溶血磷脂酸和1-花生四烯酰溶血磷脂酸。优先以花生四烯酰辅酶A为酰基供体，其次为油酰辅酶A (By similarity)。参与磷脂酸生物合成 (PubMed:18606822)。可能通过激活磷脂酶PNPLA2调节细胞甘油三酯储存 (PubMed:16679289)。参与角质形成细胞分化 (PubMed:18832586)。调节脂滴融合 (By similarity)。 {ECO:0000250|UniProtKB:Q9DBL9, ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}.
组织特异性
Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
亚细胞定位
Cytoplasm
关键词