ATP结合盒亚家族C成员3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (小管多特异性有机阴离子转运蛋白2) (多特异性有机阴离子转运蛋白D) (MOAT-D) (多药耐药相关蛋白3)
ATP结合盒亚家族C成员3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (小管多特异性有机阴离子转运蛋白2) (多特异性有机阴离子转运蛋白D) (MOAT-D) (多药耐药相关蛋白3)
O15438功能描述
ATP结合盒（ABC）家族的ATP依赖性转运蛋白，结合并水解ATP以实现多种底物（包括许多药物、毒物和内源性化合物）跨细胞膜的主动运输 (PubMed:10359813, PubMed:11581266, PubMed:15083066)。转运葡萄糖醛酸结合物如胆红素二葡萄糖醛酸酯、雌二醇-17-β-o-葡萄糖醛酸酯和GSH结合物如白三烯C4 (LTC4) (PubMed:11581266, PubMed:15083066)。也转运多种胆汁盐（牛磺胆酸盐、甘氨胆酸盐、牛磺鹅去氧胆酸盐-3-硫酸盐、牛磺石胆酸盐-3-硫酸盐）(By similarity)。对胆汁盐生理学没有实质性贡献，但为胆汁淤积肝细胞中胆汁酸和葡萄糖醛酸酯的输出提供了替代途径 (By similarity)。可能有助于调节睾丸跨血睾屏障的有机化合物运输 (Probable)。可通过减少细胞中药物的积累，赋予对多种抗癌药物、甲氨蝶呤、替尼泊苷和依托泊苷的耐药性 (PubMed:10359813, PubMed:11581266)。 {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}。
组织特异性
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules (PubMed:35307651).
亚细胞定位
Basolateral cell membrane
关键词