ABC型寡肽转运蛋白 ABCB9 (EC 7.4.2.6) (ATP结合盒亚家族B成员9) (ATP结合盒转运蛋白9) (ABC转运蛋白9蛋白) (hABCB9) (TAP样蛋白) (TAPL)
ABC型寡肽转运蛋白 ABCB9 (EC 7.4.2.6) (ATP结合盒亚家族B成员9) (ATP结合盒转运蛋白9) (ABC转运蛋白9蛋白) (hABCB9) (TAP样蛋白) (TAPL)
Q9NP78功能描述
ATP依赖性低亲和力肽转运蛋白，可将广谱肽从细胞质转运至溶酶体腔进行降解 (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30353140, PubMed:30877195, PubMed:31417173)。表现出广泛的肽长度特异性，从6肽到至少59肽，最佳长度为23肽 (PubMed:15863492, PubMed:25646430)。以相同的亲和力结合并转运较小和较大的肽 (PubMed:31417173)。偏好N端和C端位置带正电荷、芳香族或疏水残基，而不偏好带负电荷残基以及天冬酰胺和甲硫氨酸 (PubMed:15863492, PubMed:17977821, PubMed:18434309)。 {ECO:0000269|PubMed:15863492, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18434309, ECO:0000269|PubMed:22641697, ECO:0000269|PubMed:25646430, ECO:0000269|PubMed:30353140, ECO:0000269|PubMed:30877195, ECO:0000269|PubMed:31417173}。
组织特异性
Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.
亚细胞定位
Lysosome membrane
关键词