线粒体ATP结合盒亚家族B成员10 (ABC-线粒体红细胞蛋白) (ABC-me蛋白) (ATP结合盒转运蛋白10) (ABC转运蛋白10蛋白) (EC 7.6.2.-) (线粒体ATP结合盒2) (M-ABC2)
线粒体ATP结合盒亚家族B成员10 (ABC-线粒体红细胞蛋白) (ABC-me蛋白) (ATP结合盒转运蛋白10) (ABC转运蛋白10蛋白) (EC 7.6.2.-) (线粒体ATP结合盒2) (M-ABC2)
Q9NRK6功能描述
位于线粒体内膜的ATP依赖性转运蛋白，催化胆绿素从线粒体基质输出，并在血红蛋白合成和抗氧化应激中起关键作用 (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204)。参与血红素生物合成过程的早期步骤，即在铁插入原卟啉IX (PPIX) 期间发挥作用 (PubMed:22085049, PubMed:28808058)。参与铁转运蛋白mitoferrin-1/SLC25A37的稳定 (By similarity)。此外，可能参与线粒体未折叠蛋白反应 (UPRmt) 信号通路，尽管ABCB10可能不参与线粒体的肽输出 (PubMed:28315685)。 {ECO:0000250|UniProtKB:Q9JI39, ECO:0000269|PubMed:22085049, ECO:0000269|PubMed:28315685, ECO:0000269|PubMed:28808058, ECO:0000269|PubMed:34011630, ECO:0000269|PubMed:37041204}。
组织特异性
Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.
亚细胞定位
Mitochondrion inner membrane
关键词