ABCA5 Q8WWZ7

胆固醇转运蛋白 ABCA5 (EC 7.6.2.-) (ATP结合盒亚家族A成员5)

功能描述

巨噬细胞中的胆固醇外排转运蛋白，在高胆固醇水平下负责质膜上的APOAI/高密度脂蛋白(HDL)形成，并参与逆向胆固醇转运(PubMed:25125465)。可能在自溶酶体的加工过程中发挥作用(By similarity)。 {ECO:0000250|UniProtKB:Q8K448, ECO:0000269|PubMed:25125465}。

组织特异性

Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath (PubMed:24831815). Expressed in multiple regions of the brain, including the hippocampus, superior frontal and inferior temporal cortices (PubMed:25125465). Strongly expressed in neurons and moderately in microglia, with only weak expression in astrocytes and oligodendrocytes (PubMed:25125465).

亚细胞定位

Golgi apparatus membrane