AAAS Q9NRG9

阿拉丁 (Adracalin)

蛋白质信息 (UniProt)

阿拉丁 (Adracalin)

Q9NRG9

功能描述

在周围神经系统和中枢神经系统的正常发育中发挥作用 (PubMed:11062474, PubMed:11159947, PubMed:16022285)。为aurora激酶AURKA和微管负端结合蛋白NUMA1以及一部分AURKA靶蛋白的正确定位所必需，从而确保正常的纺锤体形成和及时的染色体排列 (PubMed:26246606)。 {ECO:0000269|PubMed:11062474, ECO:0000269|PubMed:11159947, ECO:0000269|PubMed:16022285, ECO:0000269|PubMed:26246606}。

组织特异性

Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947).

亚细胞定位

Nucleus, nuclear pore complex

关键词

3D-structure Acetylation Alternative splicing Cytoplasm Cytoskeleton Disease variant mRNA transport Nuclear pore complex Nucleus Phosphoprotein

外部链接

UniProt: Q9NRG9

NCBI Gene

GeneCards