ZNF521 Q96K83

锌指蛋白 521 (早期造血锌指蛋白) (LYST相互作用蛋白 3)

功能描述

转录因子，根据具体情况既可作为激活子也可作为阻遏子发挥作用。参与BMP信号传导及造血系统未成熟区室的调节。响应BMP2与SMADs结合，导致BMP靶基因的转录激活。通过与EBF1（一种参与B细胞谱系特化的转录因子）相互作用发挥转录阻遏作用；该相互作用阻止EBF1结合DNA并激活靶基因。 {ECO:0000269|PubMed:14630787}。

组织特异性

Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.

亚细胞定位

Nucleus