ZNF354C Q86Y25

锌指蛋白 354C (肾脏、缺血及发育调节蛋白 3) (hKID3)

功能描述

转录抑制因子，抑制内皮血管生成性出芽 (PubMed:15555547, PubMed:33154469)。抑制RUNX2的成骨作用，可能参与成骨细胞分化 (By similarity)。在出生后肌生成中发挥作用，可能参与卫星细胞自我更新的调节 (By similarity)。 {ECO:0000250|UniProtKB:Q571J5, ECO:0000250|UniProtKB:Q9EPU7, ECO:0000269|PubMed:15555547, ECO:0000269|PubMed:33154469}。

组织特异性

Expressed in kidney and skeletal muscle. Very low expression in brain and heart (PubMed:15555547). Strongly expressed in vascular cells such as umbilical vein endothelial cells, microvascular endothelial cells and aortic smooth muscle cells (PubMed:33154469).

亚细胞定位

Nucleus