ZNF268 Q14587

锌指蛋白 268 (锌指蛋白 HZF3)

功能描述

[Isoform 1]: 作为转录抑制因子发挥作用。抑制红细胞分化和肿瘤细胞增殖。在卵巢癌发生和进展过程中起作用。; FUNCTION: [Isoform 2]: 部分通过与I-kappa-B-kinase (IKK)核心复合物相互作用，经由TNF诱导的NF-kappa-B信号通路促进宫颈癌发生。; FUNCTION: 参与抗病毒干扰素信号通路的调节。在病毒感染期间，招募SETD4至TBK1，导致TBK1单甲基化，这对于TBK1复合物的组装和IRF3信号传导至关重要。 {ECO:0000269|PubMed:37926288}。

组织特异性

Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells.

亚细胞定位

[Isoform 1]: Nucleus