ZEB1 P37275

锌指E盒结合同源盒1 (NIL-2-A锌指蛋白) (IL2负调节因子) (转录因子8) (TCF-8)

功能描述

作为转录抑制因子发挥作用。抑制白细胞介素-2 (IL-2) 基因表达。根据cDNA的数量和细胞类型，增强或抑制ATP1A1基因的启动子活性。通过招募SMARCA4/BRG1抑制E-cadherin启动子并诱导上皮-间质转化 (EMT)。在辅抑制因子CTBP1存在下，抑制BCL6转录。正向调节神经元分化。在神经发生过程中抑制RCOR1转录激活。通过结合E box (5'-CANNTG-3') 抑制转录。在缺乏TGFB1的情况下，通过结合上游增强子区域的E-box作为COL1A2转录的抑制因子 (By similarity)。 {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}。

组织特异性

Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.

亚细胞定位

Nucleus