XRCC1 P18887

DNA修复蛋白XRCC1 (X射线修复交叉互补蛋白1)

蛋白质信息 (UniProt)

DNA修复蛋白XRCC1 (X射线修复交叉互补蛋白1)

P18887

功能描述

支架蛋白，通过介导DNA断裂修复蛋白复合物的组装参与DNA单链断裂修复 (PubMed:11163244, PubMed:28002403)。在碱基切除修复过程中负向调节PARP1的ADP-核糖转移酶活性，以防止PARP1活性过高 (PubMed:28002403, PubMed:34102106, PubMed:34811483)。识别并结合聚ADP-核糖链：特异性结合自身聚ADP-核糖基化的PARP1，限制其活性 (PubMed:14500814, PubMed:34102106, PubMed:34811483)。 {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}。

组织特异性

Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).

亚细胞定位

Nucleus

关键词

3D-structure Chromosome DNA damage DNA repair Isopeptide bond Neurodegeneration Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: P18887

NCBI Gene

GeneCards