WWP1 Q9H0M0

NEDD4样E3泛素蛋白连接酶WWP1 (EC 2.3.2.26) (Atrophin-1相互作用蛋白5) (AIP5) (HECT型E3泛素转移酶WWP1) (TGIF相互作用泛素连接酶1) (Tiul1) (含WW结构域蛋白1)

功能描述

E3 ubiquitin-protein ligase，以硫酯的形式从E2 ubiquitin-conjugating enzyme接受ubiquitin，然后直接将ubiquitin转移至靶底物。Ubiquitinates ERBB4 isoforms JM-A CYT-1和JM-B CYT-1、KLF2、KLF5以及TP63，并促进其proteasomal degradation。Ubiquitinates RNF11但不针对其进行降解。Ubiquitinates并促进TGFBR1的降解；该ubiquitination被SMAD7增强。Ubiquitinates SMAD6和SMAD7。Ubiquitinates并促进SMAD2在TGF-beta信号传导响应中的降解，这需要与TGIF相互作用。响应细胞接触抑制及在细胞膜处被募集至Crumbs复合物，从而激活Hippo信号通路 (PubMed:34404733)。Monoubiquitinates AMOTL2，促进其与LATS2的相互作用及对LATS2的激活 (PubMed:34404733)。随后LATS2磷酸化YAP1，将其从细胞核中排除，从而最终抑制YAP1驱动的靶基因转录 (PubMed:34404733)。 {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284, ECO:0000269|PubMed:34404733}。

组织特异性

Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.

亚细胞定位

Cytoplasm