WNT3A P56704

Wnt-3a蛋白

蛋白质信息 (UniProt)

Wnt-3a蛋白

P56704

功能描述

卷曲蛋白家族七次跨膜受体的配体 (Probable)。参与导致TCF/LEF家族转录因子激活的经典Wnt信号通路 (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720)。为正常的胚胎中胚层发育和尾侧体节形成所必需。为发育中神经管的正常形态发生所必需 (By similarity)。介导肠隐窝底部干细胞的自我更新 (体外) (PubMed:26902720)。 {ECO:0000250|UniProtKB:P27467, ECO:0000269|PubMed:20093360, ECO:0000269|PubMed:21244856, ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720, ECO:0000305}。

组织特异性

Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

亚细胞定位

Secreted, extracellular space, extracellular matrix

关键词

3D-structure Alternative splicing Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Proteomics identification Reference proteome Secreted

外部链接

UniProt: P56704

NCBI Gene

GeneCards