含V型免疫球蛋白结构域T细胞激活抑制因子 (血小板受体Gi24) (应激诱导分泌蛋白-1) (Sisp-1) (含V-set结构域免疫调节受体) (V-set免疫调节受体)
含V型免疫球蛋白结构域T细胞激活抑制因子 (血小板受体Gi24) (应激诱导分泌蛋白-1) (Sisp-1) (含V-set结构域免疫调节受体) (V-set免疫调节受体)
Q9H7M9功能描述
免疫调节受体，抑制T细胞应答 (PubMed:24691993)。可能通过抑制BMP4信号通路促进胚胎干细胞的分化 (By similarity)。可能刺激MMP14介导的MMP2激活 (PubMed:20666777)。 {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}。
组织特异性
Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.
亚细胞定位
Cell membrane
关键词