VEGFC P49767

血管内皮生长因子C (VEGF-C) (Flt4配体) (Flt4-L) (血管内皮生长因子相关蛋白) (VRP)

蛋白质信息 (UniProt)

血管内皮生长因子C (VEGF-C) (Flt4配体) (Flt4-L) (血管内皮生长因子相关蛋白) (VRP)

P49767

功能描述

生长因子，在血管生成和内皮细胞生长中具有活性，刺激其增殖和迁移，并且对血管通透性也有影响。可能在胚胎发生期间的静脉和淋巴血管系统血管生成中发挥作用，也可能在成体分化淋巴管内皮的维持中发挥作用。结合并激活KDR/VEGFR2和FLT4/VEGFR3受体。 {ECO:0000269|PubMed:20145116}。

组织特异性

Expressed in the spleen (PubMed:8700872, PubMed:9247316). Expressed in the lymph node, thymus, appendix and bone marrow (PubMed:9247316). Expressed in the heart, placenta, skeletal muscle, ovary and small intestine (PubMed:8617204, PubMed:8700872). Expressed in the prostate, testis and colon (PubMed:8700872).

亚细胞定位

Secreted

关键词

3D-structure Angiogenesis Cleavage on pair of basic residues Developmental protein Differentiation Direct protein sequencing Disulfide bond Glycoprotein Growth factor Mitogen

外部链接

UniProt: P49767

NCBI Gene

GeneCards