UROD P06132

尿卟啉原脱羧酶 (UPD) (URO-D) (EC 4.1.1.37)

蛋白质信息 (UniProt)

尿卟啉原脱羧酶 (UPD) (URO-D) (EC 4.1.1.37)

P06132

功能描述

催化尿卟啉原的四个乙酸侧链连续脱羧形成粪卟啉原，并参与血红素生物合成途径的第五步 (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429)。尿卟啉原异构体I或异构体III可作为底物，但只有粪卟啉原III最终能转化为血红素 (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:21668429)。在体外也能脱羧五羧基卟啉原I (PubMed:12071824)。 {ECO:0000269|PubMed:11069625, ECO:0000269|PubMed:11719352, ECO:0000269|PubMed:12071824, ECO:0000269|PubMed:14633982, ECO:0000269|PubMed:18004775, ECO:0000269|PubMed:21668429}。

亚细胞定位

Cytoplasm, cytosol

关键词

3D-structure Acetylation Cytoplasm Decarboxylase Direct protein sequencing Disease variant Heme biosynthesis Lyase Porphyrin biosynthesis Proteomics identification

外部链接

UniProt: P06132

NCBI Gene

GeneCards