UNC93B1 Q9H1C4

Unc-93同源蛋白B1 (Unc-93B1) (hUNC93B1)

功能描述

通过调节核苷酸感应Toll样受体(TLR)信号传导，在先天免疫和适应性免疫中发挥重要作用。是TLR亚群（包括TLR3、TLR7和TLR9）从内质网转运至内溶酶体所必需的，在那里它们可以结合病原体核苷酸并激活信号级联反应。可能在自身反应性B细胞清除中发挥作用。 {ECO:0000269|PubMed:19006693}。

组织特异性

Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.

亚细胞定位

Endoplasmic reticulum membrane