丝氨酸/苏氨酸蛋白激酶ULK3 (EC 2.7.11.1) (Unc-51样激酶3)
丝氨酸/苏氨酸蛋白激酶ULK3 (EC 2.7.11.1) (Unc-51样激酶3)
Q6PHR2功能描述
丝氨酸/苏氨酸蛋白激酶，作为Sonic hedgehog (SHH)信号通路和自噬的调节因子。在缺乏SHH配体的情况下作为SHH信号通路的负调节因子：与SUFU相互作用，从而使其蛋白激酶活性失活并阻止GLI蛋白（GLI1、GLI2和/或GLI3）的磷酸化。在存在SHH的情况下正调节SHH信号通路：与SUFU解离，发生自磷酸化并介导GLI2的磷酸化，从而激活GLI2并促进其核转位。在体外能磷酸化GLI2以及GLI1和GLI3，尽管效率较低。还作为自噬的调节因子：在细胞衰老后，能够诱导自噬。 {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}。
组织特异性
Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.
亚细胞定位
Cytoplasm
关键词