UBA6 A0AVT1

泛素样修饰因子激活酶6 (泛素激活酶6) (EC 6.2.1.45) (单核细胞蛋白4) (MOP-4) (泛素激活酶E1样蛋白2) (E1-L2)

蛋白质信息 (UniProt)

泛素样修饰因子激活酶6 (泛素激活酶6) (EC 6.2.1.45) (单核细胞蛋白4) (MOP-4) (泛素激活酶E1样蛋白2) (E1-L2)

A0AVT1

功能描述

通过首先利用ATP对其C末端甘氨酸残基进行腺苷酸化来激活泛素，随后将该残基连接至E1中半胱氨酸残基的侧链，生成泛素-E1硫酯和游离AMP (PubMed:35970836, PubMed:35986001)。特异性针对泛素，不激活类泛素肽。亦通过对其C末端甘氨酸进行腺苷酸化来激活UBD/FAT10结合 (PubMed:17889673, PubMed:35970836, PubMed:35986001)。在底物E2加载的特异性方面与UBE1不同。不加载细胞周期E2，例如CDC34。对胚胎发育至关重要。Isoform 2可能在泛素系统中发挥关键作用，并可能影响精子发生和男性生育力。 {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}。

组织特异性

Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.

关键词

3D-structure Acetylation Alternative splicing ATP-binding Ligase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification

外部链接

UniProt: A0AVT1

NCBI Gene

GeneCards