UBA2 Q9UBT2

SUMO激活酶亚基2 (EC 2.3.2.-) (蒽环类相关耐药蛋白ARX) (类泛素1激活酶E1B) (类泛素修饰因子激活酶2)

蛋白质信息 (UniProt)

SUMO激活酶亚基2 (EC 2.3.2.-) (蒽环类相关耐药蛋白ARX) (类泛素1激活酶E1B) (类泛素修饰因子激活酶2)

Q9UBT2

功能描述

该异二聚体作为SUMO1、SUMO2、SUMO3以及可能的SUMO4的E1连接酶。它介导SUMO蛋白的ATP依赖性激活，随后在SUMO蛋白与UBA2/SAE2上保守的活性位点半胱氨酸残基之间形成硫酯键。 {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}。

亚细胞定位

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

关键词

3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Disease variant Ectodermal dysplasia Isopeptide bond Metal-binding Nucleotide-binding

外部链接

UniProt: Q9UBT2

NCBI Gene

GeneCards