TXNRD2 Q9NNW7

线粒体硫氧还蛋白还原酶2 (EC 1.8.1.9) (硒蛋白Z) (SelZ) (TR-beta) (硫氧还蛋白还原酶TR3)

功能描述

参与控制活性氧水平以及调节线粒体氧化还原稳态 (PubMed:24601690)。维持硫氧还蛋白处于还原状态。可能在氧化还原调节的细胞信号传导中发挥作用。 {ECO:0000250|UniProtKB:Q9Z0J5, ECO:0000269|PubMed:24601690}。

组织特异性

Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).

亚细胞定位

Mitochondrion