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TSPOAP1 O95153

外周型苯二氮卓受体相关蛋白1 (PRAX-1) (外周苯二氮卓受体相互作用蛋白) (PBR-IP) (RIMS结合蛋白1) (RIM-BP1) (TSPO相关蛋白1)

蛋白质信息 (UniProt)

外周型苯二氮卓受体相关蛋白1 (PRAX-1) (外周苯二氮卓受体相互作用蛋白) (PBR-IP) (RIMS结合蛋白1) (RIM-BP1) (TSPO相关蛋白1)

O95153

功能描述

突触传递调控所必需 (PubMed:33539324)。它可能控制电压门控钙通道向突触前膜的募集,并调节神经递质释放。 {ECO:0000269|PubMed:33539324}。

组织特异性

Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus.

亚细胞定位

Cytoplasm

关键词

Alternative splicing Cytoplasm Disease variant Dystonia Intellectual disability Mitochondrion Proteomics identification Reference proteome Repeat SH3 domain