TRPV6 Q9H1D0

瞬时受体电位阳离子通道亚家族V成员6 (TrpV6) (CaT样蛋白) (CaT-L) (钙转运蛋白1) (CaT1) (上皮钙通道2) (ECaC2)

功能描述

钙选择性阳离子通道，介导多种组织中的Ca(2+)摄取，包括肠道 (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289)。对于体内正常的Ca(2+)离子稳态至关重要，包括骨骼和皮肤 (By similarity)。该通道被低胞内钙水平激活，可能包括胞内钙库耗竭，电流表现出内向整流特性 (PubMed:15184369)。失活包括快速的Ca(2+)依赖性和较慢的Ca(2+)-钙调蛋白依赖性机制；后者可能受磷酸化调节。在体外，被Mg(2+)以非电压依赖的方式缓慢抑制。与TRPV5异源组装似乎可改变通道特性。TRPV5-TRPV6异源多聚体串联体表现出电压依赖性门控。 {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}。

组织特异性

Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level) (PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

亚细胞定位

Cell membrane