短暂受体电位通道4 (TrpC4) (Trp相关蛋白4) (hTrp-4) (hTrp4)
短暂受体电位通道4 (TrpC4) (Trp相关蛋白4) (hTrp-4) (hTrp4)
Q9UBN4功能描述
形成受体激活的非选择性钙通透性阳离子通道 (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185)。作为细胞-细胞接触依赖性内皮钙进入通道 (PubMed:19996314)。形成同源离子通道或与TRPC1形成异源离子通道；与同源通道相比，异源离子通道的钙通透性降低 (PubMed:39478185)。也可通透单价离子，包括钠、锂和铯离子 (PubMed:39478185)。 {ECO:0000250|UniProtKB:Q9QUQ5, ECO:0000269|PubMed:11042129, ECO:0000269|PubMed:11713258, ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:19996314, ECO:0000269|PubMed:39478185}.; FUNCTION: [Isoform Beta]: 形成受体激活的非选择性钙通透性阳离子通道。 {ECO:0000269|PubMed:11713258}.
组织特异性
Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
亚细胞定位
Cell membrane
关键词